Best Medical Grade Air Purifier

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Updated: January 1, 2022

Looking for medical-grade air purifiers can be daunting. There are hundreds of options out there, and each product page is worded differently, which can make it really difficult to find the best one. In this guide, we tackled that challenge and came up with a list of the top ten best medical-grade HEPA air purifiers available.

We’ve summarized the main features of each unit below, along with standardized data so that you can accurately compare the coverage area, filter life, noise levels, effectiveness, and manufacturer warranty for each device.

As you evaluate each of these air purifiers, don’t forget to consider your own lifestyle, budget, and priorities. This will help you choose the best air purifier for your unique needs. We’ve listed our favorite air purifiers from many different brands below.

1. Overall Best Medical Grade Air Purifier: Purashield 500 Air Scrubber


  • Highly effective at removing airborne viruses, including SARS-CoV-2, the virus that causes COVID-19
  • H13 HEPA filter removes asthma and allergy triggers
  • Removes toxins and gasses from the air

There’s a very good reason that the PuraShield 500 Air Scrubber tops the list as the overall best medical-grade air purifier — its impressive filtration capabilities. Air purification technology from this brand has been in use for over 50 years in hospitals, airports, laboratories, and even the Sistine Chapel.

This 4-layer filtration system includes a pre-filter that catches larger particles like pet hair, dust, and dander, an impressive 22 lbs. of patented molecular filtration media, a PuraWard filter that utilizes copper and silver ions to deactivate viruses, bacteria, and mold, and a powerful H13 HEPA filter.

With a clean air delivery rate of 250 cubic feet per minute and 360-degree air circulation, it’s no wonder that this H13 HEPA cabinet filtration unit is recommended for use in schools, offices, and medical and residential care facilities.

Due to the high-capacity filtration media, the unit itself is somewhat heavy, but it’s also compact and has casters for easy mobility. With its small footprint and easy-to-operate manual controls, it’s a great choice for seniors who might be intimidated by more complex control panels.

With its high filtration capabilities, durable construction, and small footprint, the Purashield 500 Air Scrubber is ideal for anyone looking for a powerful medical-grade air purifier for their home or office. This is also a great HEPA air purifier to help tackle air pollution issues that you might be dealing with, and is considered the king of HEPA air purifiers.


  • Controls are simple and easy to operate
  • 4-level filtration including  a pre-filter, and H13 HEPA filters
  • Quiet operation at less than 60 dBA
  • Low pressure drop
  • Well known air purifier brand


  • This H13 HEPA air purifier is relatively heavy at >50 lbs
  • Replacement H13 HEPA filters can be expensive


  • Coverage Area: n/a
  • Filtration Media: 4-layer, including a pre-filter,  H13 HEPA filter and Purafil
  • Filtration Life: 6 months
  • Noise Level: <60 dBA on high
  • Particle Removal Rate: 99.97% down to 0.3 microns, 99.99% of aerosols carrying viruses
  • Warranty: 2 years

2. Runner Up for Best Medical Grade Air Purifier: EnviroKlenz Mobile UV


  • Large coverage area – up to 1,000 square feet – ideal for whole-home protection
  • Combines HEPA, UV-C, and Adsorptive Neutralization technology
  • Exceptional mold and mildew management
  • Whisper-quiet operation

If you’re looking for a medical grade HEPA air purifier that’s powerful enough to clean up your home after chemical warfare, the Enviroklenz Mobile UV unit is a really great choice. Its technology was originally designed by the US Military to destroy toxic industrial chemicals and has been used for over two decades.

Along with a powerful HEPA filter and germicidal UV-C technology, what really sets the Enviroklenz Mobile UV unit apart is its patented earth mineral technology that absorbs and neutralizes pollutants like gasses, allergens, bacteria, and viruses.

While this unit certainly isn’t the most sleek or streamlined of the HEPS air purifiers on the list, it is a workhorse that is sturdy, dependable, and energy-efficient. The simple non-digital controls are straightforward and easy to operate. Its long filter life makes maintenance easy and affordable.

The Enviroklenz Mobile UV air purifier should be a solid contender for anyone who is looking at air purifiers with medical grade filtration combined with chemical decontamination and UV-C technology.


  • Effectively absorbs and neutralizes toxins and volatile organic compounds
  • Germicidal UV-C light kills airborne microorganisms
  • Affordable filter replacement cost
  • Long filter life
  • A brand you can trust


  • Dated industrial-looking design
  • Not programmable
  • UV-C lamps, Enviroklenz cartridge, and HEPA filters will all need to be replaced
  • Doesn’t feature H13 HEPA filters


  • Coverage Area: Up to 1,000 sq. ft.
  • Filtration Media: True medical-grade HEPA filters (not H13 HEPA)
  • Filtration Life: 18-24 months
  • Noise Level: <55 dBA
  • Particle Removal Rate: 99.97% of all particles down to 0.3 microns
  • Warranty: 5 year

3. Medify Air MA 40 V2.0 Air Purifier


  • H13 HEPA filter technology removes 99.99% of particles down to 0.1 microns
  • Carbon filter removes smoke, odors, and formaldehyde
  • Lifetime warranty

The Medify MA-40 Air Purifier is sleek, stylish, and compact, making it a great air purifier for small spaces like apartments, dorm rooms, and private offices. With an H13 HEPA filter that features ionization and activated carbon technology, this unit offers powerful filtration and odor removal.

Weighing in at less than 20 lbs, this medical grade H13 HEPA air purifier is ideal for anyone facing strength or mobility issues. While it’s not the quietest unit out there, it does offer 4 separate speed settings, a timer function, child lock, and a much quieter sleep mode setting.

With affordable, easy-to-replace filters, and solid clean air delivery rate of 330 cubic feet per minute, this unit is a great choice for anyone looking for an affordable small-to-medium medical grade  H13 HEPA air purifier.


  • Easy replacement of the H13 HEPA filters
  • High quality tempered glass
  • Child lock and sleep settings
  • Can be used with or without the ionizer
  • 4-speed settings, timer, and night mode with sleep function


  • Disposable HEPA filters
  • Air cleaner ionization can produce small levels of ozone which can be irritating to the lungs


  • Coverage Area: 420 sq. ft.
  • Filtration Media: Pre-filter, H13 HEPA filter, True HEPA and active carbon composite filter
  • Filtration Life: 3,000 hours/6 months
  • Noise Level: <67 dBA
  • Particle Removal Rate: 99.9% of particles down to 0.1 microns
  • Warranty: Lifetime

4.  IQAir Genuine HealthPro Plus


  • Ultrafine particle filtration
  • Large space filtration capability
  • Programmable and remote-controlled

Not everyone is concerned with ultrafine particles, but if you are the IQAir HealthPro Plus air purifier is worth considering. With HyperHEPA (which is even better than “True HEPA”} and activated carbon filter technology, this unit removes an impressive 99.5% of particles down to 0.003 microns, over 100 times smaller than particles removed by most HEPA filters.

This air purifier is ideal for highly sensitive asthma and allergy sufferers, as well as those dealing with smoke, toxic gasses, and other ultra-fine pollutants. Daily programmable settings make it great for those who want to set it and forget it.

If you’re looking for the absolute highest level of particle filtration and large space air purification, the IQAir HealthPro Plus system should definitely make your list.


  • Intelligent filter life monitor
  • Absorbs and neutralizes odors
  • Daily programmable Monday-Sunday
  • Remote controlled
  • HyperHEPA filter only needs to be replaced every 4 years


  • Replacement cost HEPA filters can be expensive
  • Not easily moved for persons with strength or mobility issues


  • Coverage Area: up to 1,125 sq. ft.
  • Filtration Media: HyperHEPA and activated carbon filter
  • Filtration Life:
  • PreMax Pre-Filter: 18 months
  • V5-Cell Gas & Odor Filter: 2 years
  • HyperHEPA Filter: 4 years
  • Noise Level: <70 dBA
  • Particle Removal Rate: 99.5% of all particles down to 0.003 microns
  • Warranty: 10 year limited for residential use

5.  Alen FLEX Air Purifier


  • Ultra quiet operation
  • H13 HEPA filter
  • Lightweight and portable

If you’re looking for a medical grade H13 HEPA air purifier that won’t cramp your design style, the Alen FLEX Air Purifier is worth considering. This sleek, stylish option offers several customizable design panel options and a true HEPA filter to fit nearly any style or space.

The Alen FLEX Air Purifier is also ideal for light sleepers due to its soothing pink noise and ultra-quiet operation. Its True HEPA filter not only removes 99.99% of particles greater than 0.1 microns, but it also contains an anti-microbial coating that kills mold and bacteria.

With its small footprint, impressive room coverage, and lightweight portability this unit is a great medical grade H13 HEPA air purifier for apartments, dorm rooms, and offices.


  • Energy star rated
  • H13 HEPA filters
  • Customizable design options
  • Built-in air quality sensor
  • Streamlined, modern aesthetic
  • Lifetime warranty


  • High-tech controls may be intimidating for some
  • Lifetime warranty is dependent on active filter subscription


  • Coverage Area: Up to 700 square feet
  • Filtration Media: H13 HEPA filters
  • Filtration Life: 12 months
  • Noise Level: <56 dBA on high
  • Particle Removal Rate: 99.99% of particles greater than 0.1 microns
  • Warranty:  Lifetime (requires active filter subscription)

6. Okaysou AirMax8L Air Purifier


  • Ultra quiet operation
  • H13 HEPA filter and carbon filter technology
  • Easy filter replacement
  • Great for pet owners

The Okaysou AirMax8L Air Purifier is a great choice for pet owners, or anyone looking for an affordable small space medical grade air purifier. Its combined 3-stage filtration system and 2-stage duo filtration technology (which feature H13 HEPA filters, as well as a pre-filter) are designed to capture pet hair, dander, and other asthma and allergy triggers.

This air purifier is streamlined, high-tech, and affordable, making it ideal for students, those living in apartments, and a great choice for either home or office. The  HEPA filters are affordable and very easy to replace, making it painless to operate and maintain.

If you’re looking for a medical grade HEPA air purifier that’s affordable, ultra quiet, and powerful enough to handle a pet-friendly household, the Okaysou AirMax8L Air Purifier is one to consider.


  • Child lock setting
  • Dark and ultra quiet sleep mode setting
  • H13 HEPA filters
  • Auto off timer with four separate settings


  • High tech controls may be intimidating
  • Less durable plastic construction


  • Coverage Area: up to 800 sq. ft.
  • Filtration Media: Medical Grade ULTRA-DUO Filtration (H13 HEPA filters)
  • Filtration Life: 6 months
  • Noise Level: <56 dbA on highest setting
  • Particle Removal Rate: 99.97% of particles down to 0.25 microns
  • Warranty: 5 year

7. LEVOIT Air Purifier Vital 100


  • Energy efficient
  • H13 HEPA filter
  • Affordable replacement filters
  • Perfect for pet owners

We know that pet owners have specific needs when shopping for H13 HEPA air purifiers. The LEVOIT Air Purifier Vital 100 is another great option, featuring a washable preliminary filter and True HEPA filter technology that captures 99. 97% of airborne particles as small as 0. 3 microns, as well as an activated carbon filter layer that absorbs odors.

While it’s not suitable for large spaces, this air purifier is ideal for use in bedrooms and nurseries, offering whisper-quiet operation and the ability to turn the LED display off during use. At less than 10 lbs., it’s also the perfect H13 HEPA air purifier for those with strength or mobility limitations.


  • Washable preliminary filter
  • LED display can be turned off for dark operation
  • Whisper quiet 23 dBA on lowest setting
  • H13 HEPA filter techonolgy
  • Weighs less than 10 lbs.


  • No disinfectant capabilities
  • Not suitable for a large room size


  • Coverage Area: 300 sq. ft.
  • Filtration Media: TrueHEPA and activated carbon
  • Filtration Life: 6-8 months
  • Noise Level: 23–50 dBA
  • Particle Removal Rate: 99. 97% of airborne particles as small as 0. 3 microns
  • Warranty: 1 year

8. Elechomes EPI081 Air Purifier (Cheapest)


  • Ultra-compact space-saving unit
  • Combines a True HEPA filter with aromatherapy
  • Extremely quiet operation at <34 dBA on max speed

The Elechomes EPI081 Air Purifier is smaller than a gallon of milk and weighs in at less than 4 lbs. Despite its small size and room coverage,  the unit offers powerful small-space filtration that is ideal for bedrooms, nurseries, and RV’s.

Another great benefit of this tiny unit is its near-silent operation. With noise levels less than 34 dBA at max speed, it’s a great option for anyone sensitive to background noise.

Not only does the unit’s activated carbon filter absorb odors from chemicals, cooking, and pets, the Elechomes EPI081 Air Purifier can be used with any essential oil for aromatherapy purposes.

If you’re looking for an efficient, space-saving medical grade air purifier that won’t break the bank, the Elechomes EPI081 Air Purifier is a solid option.


  • Activated carbon filter absorbs odors
  • Small size great for limited spaces like nurseries and RV’s
  • Can be used with essential oils for aromatherapy
  • 360 degree air flow for increased air circulation


  • Not suitable for large spaces


  • Coverage Area: 215 sq. ft.
  • Filtration Media: TrueHEPA
  • Filtration Life: 3,000 hours
  • Noise Level: <34 dBA
  • Particle Removal Rate:  99. 97% of airborne particles as small as 0. 3 microns
  • Warranty: 18 months from date of purchase

9. Hathaspace Smart True HEPA Air Purifier 2.0


  • Highly efficient large space air purifier
  • Continuously monitors air quality
  • Energy saving “Auto” setting

The Hathaspace Smart True HEPA Air Purifier 2.0 is designed for large spaces, and with a coverage area of up to 1,500 square feet, it’s ideal for apartments, small homes, and large common areas. Its powerful 5-stage filtration system effectively filters up to 99% of particles as small as 0.1 microns.

This air purifier is as streamlined as it is powerful, with a sleek touch-screen display panel and continuous air quality monitoring. When set to auto, the unit adjusts the fan speed for optimal air quality and energy efficiency, meaning you really can set it and forget it.

The Hathaspace Smart True HEPA Air Purifier 2.0 is an ideal choice for anyone looking for energy efficient large space medical grade air purification.


  • Energy star rated
  • Auto, sleep, and manual modes
  • Washable pre-filter
  • Powerful 5-stage filtration including True HEPA filters


  • Replacement filters are somewhat expensive
  • Filters need replacing frequently – recommended at every 4 months


  • Coverage Area: up to 1,500 sq. ft.
  • Filtration Media: Cold catalyst, activated carbon, medical grade HEPA
  • Filtration Life: Every 4 months or 3,000 hours of use
  • Noise Level: <61 dBA on max speed
  • Particle Removal Rate: 99.97% of particles down to 0.3 microns and 99.95% of particles between 0.3 – 0.1 microns
  • Warranty: 5 year

10. Blueair Classic 680i Air Purifier


  • Combines electrostatic and HEPA  filter technology for improved efficiency
  • Features Blueair App and voice control with Alexa
  • Sustainable design and recyclable filters

The Blueair Classic 680i Air Purifier combines a HEPA filter with electrostatic air purification technology to create a highly efficient medical grade air purifier. This technology allows for greater airflow and clean air delivery, while using less energy than a traditional lightbulb.

It’s not the most stylish unit, this air purifier was designed with sustainability in mind. The air purifier itself is made of a combination of recycled and recyclable material, with a durable steel body, and filters that are designed to be recycled.

One of the most impressive features of this HEPA air purifier is its Wifi capabilities, which allow it to be voice controlled using Alexa, and remotely controlled via the Blueair app. This functionality allows for a wide range of programming abilities, as well as being able to monitor the current air quality even when you’re not home.

Whether you’re committed to sustainability or simply need a medical grade air purifier that’s as smart as the rest of your home, the  Blueair Classic 680i Air Purifier is certainly a great option.


  • Energy Star rated
  • Continuous air quality monitoring
  • Easy HEPA filter replacement
  • Built with sustainable materials


  • Replacement filters are fairly expensive
  • Requires Wi-fi for app and Alexa capability


  • Coverage Area: 775 sq. ft.
  • Filtration Media: HEPA and electrostatic filtration
  • Filtration Life: 6 months
  • Noise Level: <63 dBA
  • Particle Removal Rate: 99.97% of viruses and bacteria
  • Warranty: 5 year

People Also Ask

What is a Medical Grade Air Purifier?

Looking for air purifiers, in general, can be confusing, but combing through medical-grade air purifiers can be even more daunting. While the term “medical grade” isn’t regulated in regard to air purifiers, you’ll typically see air purifiers utilizing an H13 HEPA filter listed as medical grade. This is simply because H13 HEPA filter technology is the filtration level most used by hospitals and other medical facilities.

This means that any air purifier using an H13 HEPA filter could be considered medical grade. Some H13 HEPA air purifiers also include other key technology commonly used in medical space air purification, such as germicidal UV-C light, electrostatic filtration, and activated carbon to further increase levels of filtration.

What is the Best Medical Grade Air Purifier?

The PuraShield 500 tops our list of medical grade air purifiers due to its combination of high level filtration technology. Far more than a simple HEPA filter, the PuraShield 500 air purifier includes 22 lbs. of patented molecular filtration media, as well as a layer of silver and copper ions to protect the main filter.

But what really makes the PuraShield 500 stand out against other HEPA air purifiers is its effectiveness against SARS-CoV-2, the virus that causes COVID-19. This makes it by far the best medical grade air purifier for classrooms, offices, small businesses, and those who want to ensure the highest level of protection against airborne microorganisms.

What Does HEPA Mean in Medical Terms?

HEPA is an acronym for the term Highly Efficient Particulate Air (filter) and is used to identify filters that meet specific requirements laid out by the Institute of Environmental Sciences and Technology.

In medical terms, HEPA means that a filter has been tested and proven to remove up to 99.97% of particulates down to 0.3 microns, which is about 300 times smaller than the diameter of a single human hair. This means HEPA air purifiers are sufficient to remove most mold, pollen, dust, dander, viruses, and bacteria.

Why are H13 HEPA and H14 HEPA Filters Important?

Ensuring that your air purifier uses an H13 HEPA filter is important because this is the level of filtration that’s considered medical grade. In order to be classified as a HEPA filter, the filter media needs to capture 99.97% of particles as small as 0.3 microns. 

In Closing

We hope that this list of air purifiers has helped you narrow down your search. Every air purifier on this list will provide medical-grade filtration, and there really are options for every size space and budget. As you review your options, remember to factor in the frequency and cost of replacement filters, ease of maintenance, and overall durability.

The best medical air purifier will suit your space, lifestyle, and priorities, and will provide you with healthy, clean, and fresh air for years to come.